Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This can be an impurity connected to bortezomib, a proteasome inhibitor Employed in the procedure of many myeloma. Its synthesis or examine is vital for ensuring the purity and basic safety on the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor in the synthesis of abiraterone acetate, a drug Utilized in the therapy of prostate most cancers by inhibiting androgen creation.
Imatinib Intermediate (CAS NO. 152460-ten-1): A vital compound from the synthesis of imatinib, a drug that targets certain kinds of most cancers, which includes chronic myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Utilized in the synthesis of docetaxel, a chemotherapy medication that treats various cancers for instance breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): These are typically intermediates while in the synthesis of gemcitabine, an anti-cancer drug. Their review is significant for optimizing the production approach and making sure large purity.
Lapatinib Intermediate (CAS NO. 231278-84-5): Lapatinib is applied to treat breast cancer, and these intermediates are involved with its output.
Fulvestrant Intermediates: Fulvestrant is surely an estrogen receptor antagonist Employed in the remedy of breast most cancers. Many intermediates help in the synthesis of this drug.
Paclitaxel Side Chain Acid (CAS NO. 949023-16-nine): This intermediate is Employed in the synthesis of paclitaxel, a chemotherapy drug efficient in dealing with cancers for instance ovarian, breast, and lung cancer.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug Employed in the remedy of colorectal cancer and smaller cell lung CAS NO. 114611-53-9 cancer.
3-Amino-1-hydroxyadamantane (CAS 702-82-9): This compound is involved with the synthesis of adamantane derivatives, that have various programs, such as antiviral Homes.
Vildagliptin Intermediates: Employed in the creation of vildagliptin, an oral drug for style 2 diabetes that inhibits the enzyme DPP-four to regulate blood sugar amounts.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-1): This compound is associated with the synthesis of varied gluconic acid derivatives, that are Utilized in foods, 5 pharmaceutical, and industrial programs.
Canagliflozin Intermediate 2: A precursor within the synthesis of canagliflozin, a medication utilized to manage variety 2 diabetes by inhibiting sodium-glucose co-transporter two (SGLT2).